This is the unfortunate lens we biased Edmontonians have. However, this is not what the market sees and there are reasons why this site did not transact privately and is now officially hitting the market.
Your points 1 and 2 - interestingly enough this has not spurred development or raised property values. In many other cities if you build a transit line right outside your door, your property values should increase. This has not happened in downtown Edmonton.
Reality is, this is a tough go from a multifamily/hotel site, or an office site. Being on the "wrong side" or the dead side of 101 doesnt help and there are many better and cheaper sites a couple blocks away on 104st and 105st for residential. From a commercial standpoint, the vacancy rate is high and 101 street as of 2019 JLL report was the 4th most expensive commercial street in Canada.
What this site needs is a buyer from out of town who doesnt know the Edmonton market, doesnt know that CC is vacant and downtown is struggling and looks at this site as "wow a vacant site in the central business district of a major Canadian city!", or, a company not from Edmonton looking to expand into Alberta and build an owner/user office tower.